Editing gut bacteria is the next frontier for CRISPR
March 11, 2023
Our Guided Biotic technology makes use of the naturally occurring immune system that many bacteria possess. By careful redirection of this immune system we are able to remove unwanted bacteria and improve nutrition in the gut of production animals.
HOW GUIDED BIOTICS® WORK
Guided Biotics® were founded on patented CRISPR-Cas technology. CRISPR is an acronym that describes repeating sequences of DNA that form part of the natural bacterial immune system that has developed to recognise and precisely degrade DNA of invading elements such as bacterial viruses.
Guided Biotics® uses CRISPR to identify and target specific sequences of DNA in the target unwanted bacteria.
FOLIUM Science has developed a proof of concept of the first product which has resulted in a commercial partnership to distribute Guided Biotics® worldwide following regulatory approval.
Guided Biotics® are designed to be exquisitely specific in targeting the unique sequences of DNA that are only found in the target unwanted bacteria and can be delivered to animals in drinking water or feed via friendly bacteria or friendly viruses.
FOLIUM Science has developed unique Guided Biotics to selectively remove unwanted bacteria from livestock. Priority targets for poultry applications are Salmonella (all serotypes) and other zoonotic, performance reducing, spoilage and wastage bacteria.
In partnership with the University of Bristol and the Quadram Institute of Bioscience, FOLIUM Science is in a position to launch their first product range, BiomElix.
FOLIUM Science has developed Guided Biotics® to selectively remove unwanted bacteria from livestock. Priority targets for poultry applications are Salmonella (all serotypes) and other zoonotic, performance reducing, spoilage and wastage bacteria.
With the support of University of Bristol and the Quadram Institute of Bioscience, FOLIUM Science is developing their first product range, BiomElix, across a number of unwanted bacteria.
GUT MICROBIOME MODULATION
FOLIUM Science has expanded their Guided Biotics® technology to work with the microbiome of the animal gut. Here the aim is to reduce the production of chemical “metabolites” which are harmful to the animal and our environment, whilst retaining those metabolites that are beneficial to a healthy and balanced microbiome.
The unique effect of this application is on reducing greenhouse gas emissions and increasing the nutritional value and, therefore feed conversion rates by releasing nutrients more effectively for the animal to utilise; making the production system of animals sustainable for future generations.
FOLIUM Science has developed unique and patented technology that will selectively remove undesirable or pathogenic bacteria. This technology is called Guided Biotics.
FOLIUM Science, BiomElix and Guided Biotics are all the registered trademarks of Folium Food Science Limited.
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